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Whereas intrinsic death theory proposes activation of apoptotic cascade due to internal defects in melanocytes as the melanocyte death mechanism

Propagation approaches: this approach allows the discovery of disease-gene, disease-disease, and disease-target relationships (Picart-Armada et al., 2019)

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Although KKAy, db/db, and ob/ob mice are all used as genetic mouse models of T2DM, KKAy mice were the least expensive of these and were readily available